3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings
نویسندگان
چکیده
منابع مشابه
MDMA -induced neurotoxicity in rats
Ž . Ž . The role of nitric oxide NO in the long-term serotoninergic neurotoxicity induced by " 3,4-methylenedioxymethamphetamine Ž . v Ž . Ž y1. Ž . MDMA in rats was investigiated. Pretreatment with N -nitro-L-arginine L-NOARG 10 mg kg , a nitric oxide synthase NOS Ž . Ž y1. inhibitor, partially protected against long-term serotonin 5-HT depletion induced by MDMA 40 mg kg in frontal cortex and ...
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The drug 3,4-methylenedioxymethamphetamine (MDMA) is a serotonergic neurotoxicant that causes hyperthermia and depletion of serotonin (5-HT) and 5-hydroxy-indole-3-acetic acid (5-HIAA) in the central nervous system. Formation of neurotoxic metabolites of MDMA, e.g., 2,4,5-trihydroxy-methamphetamine and 2,4,5-trihydroxyamphetamine, involves hydroxyl and/or superoxide free radicals. The present s...
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The neurotoxicity of (6)-3,4-methylenedioxymethamphetamine (MDMA; “Ecstasy”) is influenced by temperature and varies according to species. The mechanisms underlying these two features of MDMA neurotoxicity are unknown, but differences in MDMA metabolism have recently been implicated in both. The present study was designed to 1) assess the effect of hypothermia on MDMA metabolism, 2) determine w...
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The neurotoxicity of (±)-3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") is influenced by temperature and varies according to species. The mechanisms underlying these two features of MDMA neurotoxicity are unknown, but differences in MDMA metabolism have recently been implicated in both. The present study was designed to 1) assess the effect of hypothermia on MDMA metabolism, 2) determine w...
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A series of experiments administered a low dose range (0, 1.25, 2.5 and 5 mg/kg) of (+/-)-3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') to rats and assessed them in a variety of standard tests of anxiety. These tests included the emergence and elevated plus-maze tests, social interaction, cat odor avoidance and footshock-induced ultrasonic vocalizations. MDMA increased anxiety-related beh...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2006
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-006-0322-6